As a formulator, you’re doubtless no stranger to collagen. Typically hailed as the last word key to youthful, radiant pores and skin in mainstream media, this important protein serves because the pores and skin’s structural spine, delivering energy and elasticity. Nevertheless, as we age, collagen manufacturing declines, resulting in the inevitable indicators of ageing.
Lately, a surge of on-line claims means that collagen-infused skincare merchandise and dietary supplements can increase the pores and skin’s pure collagen manufacturing. However is there any scientific advantage to those assertions, or are they merely myths? And does collagen actually work for the pores and skin?
On this submit, we delve into the science behind collagen and its reputed advantages, exploring the best collagen-boosting substances accessible. We’ll additionally information you thru easy methods to formulate with these highly effective, in-demand elements so you may create high-performance skincare merchandise.
What’s collagen?
Collagen is a protein in our pores and skin and the first structural part of the dermis, our second pores and skin layer. Produced by fibroblast cells within the dermal layer, kind I collagen supplies energy and assist to the pores and skin. Nevertheless, its manufacturing declines with age, which generally results in wrinkles and superb strains (i).
Why is collagen vital?
Collagen is a very powerful structural protein in our pores and skin, which supplies structural integrity and resilience to the pores and skin. Together with elastin, it’s accountable for the pores and skin’s firmness and elasticity. As we age, many modifications happen which result in wrinkling, lack of elasticity, sagging, and different ageing indicators.
Understanding how the pores and skin works and the various kinds of collagen – sorts I and III being the principle cutaneous sorts (i)- may help you formulate one of the best skincare for mature pores and skin.
You will discover out extra in regards to the pores and skin barrier under:
Pores and skin barrier 101: important information for pure skincare formulation
What impacts collagen manufacturing?
Collagen manufacturing declines with age, as fibroblasts change into much less lively once you attain early maturity. It can be affected by sure life-style selections, in addition to extrinsic (UV-radiation, air pollution) and intrinsic components (genetics, age, ethnicity, hormones) (i).
Collagen-based skincare: fable or reality?
Now that extra about collagen, you’re most likely questioning if incorporating plant-based or maritime collagen in your skincare formulations can increase the pure ranges of collagen throughout the pores and skin. In any case, lots of people on the web are claiming that including collagen to their skincare routine- both in topical, injectable, or ingestible forms- may help stimulate pure collagen manufacturing.
Sadly, that’s not true. Whereas a topical collagen cream may assist moisturise your pores and skin, it gained’t increase pure collagen manufacturing. That’s as a result of the molecular weight of collagen is much too huge to penetrate the dermis successfully and attain the dermis, the place collagen is situated.
Nevertheless, different compounds, comparable to retinoids or vitamin C, can enhance the biosynthesis of collagen (ii). There are additionally research with hydrolysed collagen peptides which present promise in reaching the dermal layer (iii).
High 5 collagen-boosting substances
Whereas topical collagen gained’t affect pure collagen manufacturing, some substances may help increase connective tissue manufacturing, thereby rejuvenating pores and skin and different tissues (ii).
These substances are thought of the last word anti-ageing substances, as they aim present wrinkles, reasonably than stop future indicators of ageing.
Hyaluronic acid
Primary on this checklist is hyaluronic acid, a polysaccharide naturally current within the pores and skin, accountable for the pores and skin’s hydration. As a beauty ingredient, hyaluronic acid is a humectant which may help hydrate and moisturise the pores and skin.
Lately, a research (iv) discovered that hyaluronic acid can even assist stimulate collagen and elastin manufacturing, and shows attention-grabbing regenerating and repairing properties, which management the inflammatory course of and lively collagen synthesis. Whereas extra proof is required to verify this, the analysis is trying promising.
Discover extra about hyaluronic acid in our devoted Mini Lab or our devoted weblog submit under:
Hydration revolution: formulator’s information to hyaluronic acid
Add hyaluronic acid powder to your water-based formulations, together with gels, toners, serums, lotions, and lotions. We advocate you utilize low-molecular-weight hyaluronic acid, because it penetrates deeper into the pores and skin, and due to this fact has a greater likelihood to stimulate collagen manufacturing, however you may additionally add high-weight molecular hyaluronic acid for fast hydration. You possibly can additionally mix hyaluronic acid with different actives for a synergetic impact.
Bakuchiol
Whereas retinol reveals robust talents to assist restore kind I collagen in naturally aged and photoaged pores and skin (v), we selected to checklist bakuchiol as an alternative as one of many prime collagen-boosting substances in the marketplace. A pure various to retinol, bakuchiol is much gentler on the pores and skin, is simple to supply, and doesn’t have the identical photosensitising points as retinol.
A 2014 DNA microarray research discovered that bakuchiol works equally on the pores and skin as retinol by serving to to stimulate cell turnover, kind I, III, and IV of collagen; and cut back seen indicators of ageing and hyperpigmentation (vi).
Discover out extra about bakuchiol in our devoted Mini Lab or these weblog posts:
High 5 pure retinol options and why it is best to use them
The way to formulate a bakuchiol magnificence focus
As a robust antioxidant and collagen stimulator, bakuchiol is a superb addition to the cool-down section of your mature skincare formulations.
Vitamin C
Vitamin C is without doubt one of the most researched nutritional vitamins in the marketplace and is a tremendous antioxidant which may help neutralise free radicals within the pores and skin, brighten the pores and skin, and enhance regulation of kind I and III of collagen (vii). Nevertheless, it’s notoriously troublesome to formulate with.
Whereas ascorbic acid has been broadly researched, it’s extremely unstable, oxidises quick, and might set off pores and skin sensitivities. You possibly can use pure options as an alternative, however extra analysis is required to verify their properties. Ascorbyl glucoside, also called AA2G™, is without doubt one of the most promising thus far, with good stability and excessive antioxidant exercise.
Study extra about vitamin C and its options in our devoted mini lab or the posts under:
4 Vitamin C myths each formulator ought to know
The advantages of vitamin C in skincare
Greatest types of vitamin C in skincare
The way to formulate a restoring vitamin C face serum
You need to use this water-soluble powder within the cool-down section of your emulsions. Alternatively, you may use ascorbyl tetraisopalmitate, an oil-soluble type of vitamin C, which might mitigate indicators of untimely pores and skin ageing, cut back hyperpigmentation, and assist collagen synthesis.
Inexperienced tea
Whereas we’re on the subject of antioxidants, let’s discuss inexperienced tea. Extracted from the Camellia sinensis leaves, this ingredient is thought for its excessive quantity of catechins, a category of polyphenols famend for his or her antioxidant properties.
Some research (viii) have proven that utilizing topical skincare containing inexperienced tea extract may help combat free radicals and cut back the manufacturing of collagen-degrading enzymes within the pores and skin, in addition to increase collagen manufacturing in human pores and skin cells.
Discover out extra about inexperienced tea in these posts:
Leaf to lotion: the advantages of inexperienced tea in cosmeticsThe way to make a skin-loving inexperienced tea serum
The way to make a inexperienced tea and lemon physique polish
Add inexperienced tea extract to your skincare formulations for smoother and resilient pores and skin. This explicit ingredient may be very versatile, because it’s accessible in powder, hydrosol, wax, glycerite, and oil varieties. Remember that catechins are very delicate to oxygen and light-weight, so be sure to retailer your substances appropriately.
Peptides
Final, however actually not least, we’ve received peptides. Naturally current in our pores and skin as quick chains of amino acids, peptides are additionally among the many hottest substances in the marketplace.
There are 4 sorts of beauty peptides, however we’re largely taken with sign peptides and enzyme-inhibitor peptides right here. Whereas peptides stimulate collagen manufacturing, enzyme-inhibitor peptides cut back collagen breakdown. When utilized topically, peptides may help stimulate the manufacturing of dermal collagen and elastin, that are accountable for the pores and skin’s construction, firmness, and elasticity (ix).
Discover out extra about peptides in our devoted Mini Lab and the information under:
You’ll be able to select from many plant-based peptides, together with FSS hexapeptide 1, hydrolysed pea protein, hydrolysed lupin, and lots of others. These are greatest added within the cool-down phases of your serums, lotions, and lotions.
Collagen: well worth the hype?
Now that you simply’ve realized extra about collagen, you’re most likely questioning if collagen is well worth the hype. As a beauty ingredient and by itself, we wouldn’t advocate it, as its molecular weight is just too huge to do something for the pores and skin. Nevertheless, you may provide the pores and skin with collagen-boosting substances to assist stimulate the pure manufacturing of collagen and elastin within the pores and skin.
At Formulation Botanica, we’re all about constructive ageing and wholeheartedly imagine that ageing is a privilege. In any case, ageing is a standard course of all of us undergo, and we must always all formulate with that in thoughts. We’re right here that can assist you harness the facility of botanicals that can assist you create superb formulations, and information you alongside the way in which.
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References & Additional Studying
(i) Reilly et al, 2021. Pores and skin collagen by means of the life levels: significance for pores and skin well being and wonder
(ii) Gref et al, 2020. Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen manufacturing in human pores and skin
(iii) Hong et al, 2019. Preparation of low-molecular-weight, collagen hydrolysates (peptides): present progress, challenges, and future views
(iv) Tanha et al, 2023. A green-based strategy for non-invasive pores and skin rejuvenation: potential software for the pores and skin
(v) Solar et al, 2016. Topical retinol restores kind I collagen manufacturing in photoaged forearm pores and skin inside 4 weeks
(vi) Chaudhuri et al, 2014. Bakuchiol: a retinol-like purposeful compound revealed by gene expression profiling and clinically confirmed to have anti-ageing results
(vii) Niaimi et al, 2017. Topical vitamin C and the pores and skin: mechanisms of motion and scientific softwares
(viii) Koch et al, 2019. Purposes of tea (camellia sinensis) and its lively constituents in cosmetics
(ix) Jeong et al, 2019. Anti-wrinkle advantages of peptides complicated stimulating pores and skin basement membrane protein expression
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Ariane is Formulation Botanica’s content material creator and an lively member of the coed neighborhood. She has labored as knowledgeable journalist, blogger, copywriter and editor earlier than becoming a member of Formulation Botanica full-time in 2024.
